P-114: MULTIPLE MYELOMA ASSOCIATED WITH OTHER PRIMARY MALIGNANT NEOPLASMS: EPIDEMIOLOGICAL CHARACTERISTICS OVER 20 YEARS OF HOSPITAL CANCER REGISTRY

Introduction:
Multiple myeloma, a rare disease accounting for 1-2% of global neoplasms, is diagnosed through clinical examination and IMF criteria, with incidence increasing with age. Treatment includes medications and sometimes autologous bone marrow transplantation, significantly improving prognosis and survival rates. Advances in treatment have led to deeper, lasting responses, but also highlight the importance of studying other primary neoplasms influenced by patient, disease, and treatment factors. Descriptive epidemiological studies are essential to identify patterns and formulate analytical hypotheses in cancer.

Methods:
This study examines the sociodemographic, epidemiological, and clinical profiles of patients with myeloma and other primary malignant neoplasms treated at the AC Camargo Cancer Center between 2000 and 2021. It analyzes common neoplasms associated with myeloma, focusing on their topography, morphology, and diagnostic timing. Using ACCCC Registry data, the retrospective study excludes non-melanoma skin cancer and explores variables like sex, age, and types of neoplasms, along with their temporal relationship to myeloma diagnosis.

Results: A total of 79 records were analyzed, with 69 deemed valid for epidemiological analysis of myeloma linked to other primary neoplasms. The median age at myeloma diagnosis was 69 years, ranging from 48 to 91 years. Prostate adenocarcinoma was the most common primary neoplasm at 25%, followed by breast neoplasms at 17% and colon adenocarcinoma at 16%. Non-Hodgkin lymphomas accounted for 12% of cases, making them the most prevalent neoplasms.
Analysis revealed that 21.7% were diagnosed with myeloma before another neoplasm, 59.4% were diagnosed with a primary neoplasm before myeloma, and 18.8% were diagnosed simultaneously with both, underscoring the importance of ongoing monitoring for cancer patients due to the potential development of additional neoplasms.

Conclusions: Conducting descriptive studies with an epidemiological profile is extremely important, especially in the field of cancer. This approach allows for a detailed survey of the population, identifying patterns that, in turn, enable the formulation of analytical hypotheses. In the specific context of multiple myeloma, where patient survival has increased due to current treatments and disease-related prospects, such studies gain significant relevance. This is due to the emerging occurrence of other primary neoplasms in this population, making it imperative to understand these phenomena to improve management and care strategies.